Semaglutide is not recommended during pregnancy, and women of childbearing potential should discontinue the medication at least two months before planned conception
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The initial in vivo assessment for safety and toxicological effects showed it to be well tolerated on models of rat, monkey and dog [1]
Your provider should document baseline tolerability, establish a clear escalation plan, and define stopping criteria if serious adverse events emerge
If the arrhythmia persists, they use isoproterenol or dopamine as a bridge to temporary pacing (11)(21)
Methods A comprehensive literature review of PubMed, Embase, and Elsevier databases identified 17 relevant studies published between 2013 and 2024 that investigated the role of GLP-1 receptor agonists in bone metabolism, wound healing, and orthopedic surgery